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Nanocarriers could facilitate an easy uptake of ferroptosis inducers coupled with genes or PDT or US irradiation to affect the growth of lethal cells
reported that endogenous itaconate directly binds to GSDMD by covalently modifying the thiol group of Cys77 and may interfere with the caspase-GSDMD interaction, thereby inhibiting pyroptosis and tissue damage [207]

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