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Ther-apeutic potential of neurotrophic factors in Alzheimers Disease

An emotional or anticipated stress response can happen without a primary sensory stimulus because limbic brain regions will stimulate the PVN when activated

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Using multiple ECM labeling and imaging assays, from super-resolution optical imaging to nanoscale secondary ion mass spectrometry, both in culture and in brain slices, we find that a key ECM protein, Tenascin-R, is frequently endocytosed, and later resurfaces, preferentially near synapses
