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As we mentioned already, signaling by activated G-GTP is terminated by GTP hydrolysis, a reaction catalyzed by the G subunit itself that yields the inactive form, G-GDP (Figure 2)
As expected, the loss of membrane integrity in wild-type HeLa cells upon treatment with RSL3 or CHP was mostly prevented by liproxstatin-1 (Extended Data Fig
10.1016/j.pt.2020.04.010 [DOI] [PubMed] [Google Scholar] 232.Misslinger M, Hortschansky P, Brakhage AA, Haas H
Schoene, R
