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Description
PT2385 is one of the very few HIF-2 inhibitors investigated in preclinical models of GBM and works by preventing allosteric heterodimerization with HIF-1 when it binds to HIF-2 PAS-B domain (156)

Mechanisms of Action*

Med Hypotheses 143:110102 Yoshikawa T, Naito Y (2000) What is oxidative stress

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