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For example, the anticancer agent tamoxifen is converted into tamoxifen N-oxide by FMO [4]

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The fact that the aforementioned difference in the expression of neuropathy results in more severe neuropathic deficits in type 1 than in type 2 diabetic models in spite of similar levels of hyperglycemia seems to suggest a direct pathogenetic role of insulin (and/or C-peptide) deficiency [32]

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