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An increase was seen when injected intraperitoneally but to a lesser extent [145]

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Cyclooxygenase-Derived Octadecanoids The stereospecific removal of the LA 11-pro( S ) hydrogen by COX enzymes forms two hydroperoxides, 13( S )-HpODE and 9( R )-HpODE, that are reduced into two main monohydroxylated products 13( S )-HODE and 9( R )-HODE (Scheme 10)

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& Gruss, P

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With a deeper understanding of pathological mechanisms involved in lung diseases, the discovery of new targets and therapeutic agents, and progress in the development of INDDs, more medications are suitable for pulmonary delivery, offering improved treatment effectiveness and fewer side effects

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