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Description
In advanced cancer, the high expression of GPX3 clears excess ROS in the extracellular environment, maintaining the redox homeostasis in the TME, protecting tumor cells and enhancing drug resistance (88)

The liver contains a protein called alpha-tocopherol transfer protein (alpha-TTP), which is responsible for maintaining higher levels of alpha-tocopherol in the body

Analysis performed under standard reversed-phase chromatographic conditions with LCMS/MS confirmation of molecular mass

And finally, potential synergy: therapies targeting hypoxia and HIF-1 may have the potential to create synergies with existing drugs compared to existing treatments, thereby enhancing the therapeutic effect (233)
