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These effects are initiated through ROS generation and PRR signaling (e.g., TLRs), which in turn trigger downstream MAPKs and NF-B signaling pathways

[DOI] [PubMed] [Google Scholar] 73.Zerahn B., Kofoed-Enevoldsen A., Jensen B.V., Molvig J., Ebbehoj N., Johansen J.S., Kanstrup I.L

The localized delivery of mRNA-based immunotherapies presents a promising strategy due to its capacity to generate targeted immunomodulatory proteins

3A and Fig
