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However, no research directly compares continuous use versus cycling protocols (such as 12 weeks on, 4-8 weeks off), leaving optimal long-term strategies somewhat uncertain
Frequency: one subcutaneous injection each day on a 5-on / 2-off pattern, titrating up as tolerated
Bottom line Existing evidence comparing oral with IM vitamin B12 is suboptimal
Indeed it has been hypothesized that depression and vascular disease may be different manifestations of the same genetic substrates 79
