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TABLE 3 Role of non-CYP450 proteins involved in drug metabolism/transport and impact of cigarette smoking on their activity

What this means practically: if you have an MTHFR variant AND estrogen dominance symptoms, the 3-Supplement Protocol supports the COMT methylation pathway specifically because methylfolate feeds the chain that produces SAMe, and SAMe is what COMT needs to clear estrogen metabolites

A study comparing patients with gestational diabetes mellitus and healthy pregnant women found that consumption of white wheat bread resulted in 45.5% higher insulin secretion and a 9.6% increase in first-hour postprandial blood glucose levels compared to sourdough whole grain bread in both groups (42)
