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The most common changes seen are weight loss, poor hair quality, halitosis/bad breath (with or without mouth ulcers), variable appetite, lethargy and depression

PLoS Pathog 16:e1008668 Zhang W, Weng J, Yao L, Jia P, Yi M, Jia K (2020b) Nectin4 antagonises type I interferon production by targeting TRAF3 for autophagic degradation and disrupting TRAF3-TBK1 complex formation

Excessive ROS can induce oxidative DNA damage, including 8-OHdG

Adaptation to hot climate and strategies to alleviate heat stress in livestock production
