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NAC also led to a 23% increase in GSH levels in the medial prefrontal cortex (GSH mPFC ) as measured by 1 H magnetic resonance spectroscopy

7.5 Improving OSC bioavailability: delivery system design One of the major practical barriers to clinical translation of many OSCs is their poor bioavailabilitydue to instability (e.g., rapid degradation of thiosulfinates), poor aqueous solubility, susceptibility to first-pass metabolism, and limited systemic exposure
L.Al-WakeelY.WarrickN.HaleA

Psychiatry 24 (7), 10271039
