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Additionally, the neuronal activity of Nrf2 is limited by the high content of the Cullin 3 protein, contributing to the proteasome degradation of Nrf2 [18]

Recent studies have demonstrated that neutrophil extracellular traps (NETs) induce the activation of Toll-like receptor 9 (TLR9) signaling pathway in septic patients, thereby triggering endoplasmic reticulum (ER) stress in intestinal epithelial cells (IECs), leading to increased intestinal inflammation, apoptosis of IECs, tight junction injury, and ultimately compromising the mechanical barrier of the intestinal mucosal epithelium

Vitamin C helps recycle the body's glutathione, which can lead to a more even and radiant skin tone over time