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Clinical trials have demonstrated substantial improvements in hemoglobin A1c reduction (up to 2.5% decrease) in diabetes patients, while weight loss of up to 20% was observed primarily in adults with obesity without diabetes in the SURMOUNT-1 trial

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Recognition of solubilized apoproteins from delipidated, oxidized low density lipoprotein (LDL) by the acetyl-LDL receptor
