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136 In addition, acquired astrocytopathies are prominent in hepatic encephalopathy (in which astrocytes lose their homoeostatic capabilities 137 ) and in neuromyelitis optica, in which the astrocyte protein, AQP4 is the subject of autoimmune attack, leading to dysfunction and death of astrocytes resulting in pronounced inflammation and degeneration of neural tissue
doi: 10.1002/chem.201602795
Mittal (55) and others compared mice with overexpression or knockout of the TWEAK gene and found that skeletal muscle atrophy and fast muscle fibers increased significantly after 4 to 5 months of overexpression, with increased Fn14 expression level and the opposite finding in the knockout group

It is however important to emphasize that these processes do not touch the endothelium physically, but do so at specialized joints called peg-and-socket junctions (S-Pereira et al., 2012)
