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The study also does not explore the effect of Roflumilast on Methotrexate (MTX) pharmacokinetics or on MTXs anticancer efficacy
Oxidative stress is a key factor in the inflammatory responses associated with lung diseases, as it triggers the upregulation of redox-sensitive transcription factors, which promote the expression of pro-inflammatory genes
Johansson and Mannervik, 2002)
Both Asc and MDA radicals can reduce the phenoxy radical
