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Description
As acute pancreatitis resulted in severe oxidative modification of proteins, an intensive increase (roughly 70%) in the content of 2,4-dinitrophenylhydrazine (DNPH)-reactive protein carbonyls was obtained in the cerulein-induced pancreatic tissue (0.2301 U/mg 0.02078) when compared to that of the non-cerulein-treated control (0.1321 U/mg 0.00925)
After running multiple biochemical assays, the authors learned that NAC was able to prevent NO-induced apoptosis, overproduction of ROS, p53 up-regulation and caspase-3 activation
In: Mingos, D
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