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Description
Phase I biotransformation seems to be enzymes that catalyzes oxidation, reduction or hydrolyze reactions, it usually converts substrates to more polar forms by introducing or unmasking a functional group (e.g., OH, NH2, or SH)
Melse-Boonstra, A
Approximately 3% of hospital admissions in the US are linked to drugdrug interactions and a Dutch study reported values as high as 8.4%
Effects on the Endocrine System Opioids inhibit the secretion of adrenocorticotropic hormone (ACTH), cortisol, and luteinizing hormone (LH) in humans (see ADVERSE REACTIONS)
