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National Institute of Arthritis and Musculoskeletal and Skin Diseases

In this context, a particularly relevant example is the Wistar-Kyoto (WKY) rat strain, which was originally developed as a normotensive control group for studies involving the spontaneously hypertensive rat (SHR) 12 , but was later shown to exhibit a depression-like phenotype comparable to that observed in patients, leading to its current recognition as a well-established animal model of endogenous depression 13,14

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13 Early treatment with high doses of vitamins A and E can reduce the neuropathy and retinopathy