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In a phase I trial (NCT01041222), an ASO designed to inhibit SOD1 expression (ISIS 333611) was delivered by a single intrathecal infusion (L34) for 11 h and 22 min using an infusion pump at increasing doses (0.15 mg, 0.5 mg, 1.5 mg, 3 mg), and results showed that it was safe and well-tolerated [32]

Use of ursodeoxycholic acid in liver disease

218 In a more recent study in rat primary astrocytes, pre-conditioning with 10 or 20 nM methotrexate (corresponding to 5 or 10 g of the drug) enhanced the anti-oxidant defence mechanisms in these cells, expressed as the ratio of reduced to oxidized glutathione, as well as cell viability against a higher dose of methotrexate (500 nM or 0.23 mg/L)

doi:10.1016/j.urology.2005.03.060 Li K, Liang S, Shi Y, et al