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These findings do not establish a direct cause-and-effect relationship, but they suggest that long-term high-dose supplementation may not be necessary for individuals with adequate B12 status
In addition, they often lead to metabolic disorders (9, 10)
A gut microbiome issue
Using our protocol we have also prepared the linaclotide drug for chronic constipation and irritable bowel syndrome, made of a 14 AAs peptide and bearing three disulfide bonds (Fig
