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There was an overall reduction in drinking in both XR-NTX and buprenorphine/naloxone groups

Our studies suggest new insights that might contribute to the clinical effects observed in some cognitive and behavioral symptoms of HE, such as irritability, sleep disorders, psychomotor retardation, and thinking disturbances, which all negatively impact quality of life and healthcare expenses

The two therapies work in tandem: one purifies at the cellular level, the other clears the pathways that carry waste away

Dosing Regimen: Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks initially, followed by 1 mg every 2 to 3 months (if deficiency is not diet-related)