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It often leads to failure to thrive, hypoalbuminemia, metabolic derangements, and ultimately severe dehydration

Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation

However, provided variations in the water content within the sample are much smaller than the variations in the metabolite levels, variance shared between normalized metabolite signals can be assumed to arise largely from shared variance in metabolite concentrations [52]

Similar to these findings, the coexistence of anemia and OWOB had been reported in many countries undergoing nutrition transition 53,54,55