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10.1038/ng1196-361 14
8 The mechanisms of APAP-induced cell death, which apply to both animals and humans, include the formation of the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI) by cytochrome P450 2E1 (Cyp2E1), depletion of hepatic GSH, and protein adduct formation, primarily in mitochondria
This dual action (build new, clear old) results in a more thorough skin remodeling effect
Substance P via NK1 receptor facilitates hyperactive bladder afferent signaling via action of ROS
