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Simvastatin, a semisynthetic lipophilic HMG-CoA reductase inhibitor, has demonstrated anti-fibroid properties by inhibiting fibroid cell proliferation, decreasing the expression of proliferative markers such as Ki67, and promoting apoptosis of fibroid cells (in a dose-dependent manner) in in vitro studies [81,83]

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Detailly, APS provokes the formation of the BECN1-xCT complex to reduce GPX4 expression in urothelial carcinoma cells through activating AMPK/BECN1 signaling, thereafter inducing ferroptosis and ultimately inhibiting UC progression [52]

[DOI] [Google Scholar] 227.Orosa M., Torres E., Fidalgo P., Abalde J