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When glutathione levels drop, the immune system effectively "loses its brakes," allowing for the overproduction of pro-inflammatory cytokines like Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-)

Mareks disease virus induced various temporal chromatin signatures to bursa of Fabricius chickens at different stages of Mareks disease development, and the differential H3K27me3 was significantly enriched in pathways related to the immune response (Mitra et al., 2015