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Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders

GSTM1 is present as active ( GSTM1*A and GSTM1*B ) or null ( GSTM1*0 ) alleles, and its protein product is a xeno-compound-metabolizing enzyme that aids in the detoxification of both exogeneous and endogenous compounds ( GSTM1 have an increased risk of both lung and bladder cancers, two diseases that have strong environmental associations (Seidegard et al., 1990

10.1016/j.brainres.2015.03.018 [DOI] [PMC free article] [PubMed] [Google Scholar] Rossi R., Dalle-Donne I., Milzani A., Giustarini D

Therefore, mechanism I involves efflux of solvents, organic acids, and H + ions, which improve absorption of Zn-complexes and release Zn 2+ ions for absorption by root epidermal cells