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AL, also called age spots, are brownish pigmented macules with irregular borders and size of a few millimeters

doi: 10.1016/j.jviromet.2024.114990

The combination of sofosbuvir (200 mg or 400 mg once daily) and PEG-IFN/RBV for 12 weeks demonstrated efficacy, reaching SVR12 of 91% in HCV-1 and 92% in HCV-2/HCV-3, while it was 58% in placebo plus PEG-IFN/RBV group.[86] Recently, the LONESTAR-2 study assessed the combination of sofosbuvir plus PEG-IFN/RBV in 47 previous treatment-failure HCV-2 and HCV-3 patients (55% with compensated cirrhosis) treated for 12 weeks

Noticeably, these substances, except for TNF-, are all important components directly involved in glucose metabolism, suggesting APOC3 and APOA5 dysregulation may contribute to diabetic dyslipidemia