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Cohorts were retained only when acquisition protocols, preprocessing steps and clinical annotations were harmonized, thereby reducing immortal-time bias and ensuring consistency in outcome definitions

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Another was from 1998 and is titled, "Patterns and correlates of cannabis dependence among long-term users in an Australian rural area." It is not a great leap to surmise that Australians in the countryside smoking whatever marijuana was available to them illegally in 1998, or patients in a psychiatric hospital, might be substantively different from current American cannabis users