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Interestingly, in pancreatic ductal adenocarcinoma (PDAC), uncoupling protein 2 (UCP2) can transport the aspartate derived from glutamine metabolism from mitochondria to the cytoplasm to generate NADPH, and silencing UCP2 can significantly inhibit the growth of PDAC

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L-histidine can also be broken down into histamine by bacterial enzymes, as can -aminobutyric acid (GABA) from glutamate [36, 37]

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