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Genetic deletion of PPAR in macrophages results in decreased FAO and alternative activation while increasing the production of inflammatory cytokines, making them more susceptible to obesity and impairing glucose metabolism (51)

Eur J Pharmacol 756:6774

It was about the places, the music, the exploration, and the memories attached to them

This is consistent with the general upregulation of lipogenic genes in pregnant adiponectin KO mice, including those coding for diacylglycerol transferase-1 ( Dgat1 ), fatty acid synthase ( Fasn ), acetyl-CoA carboxylase ( Acaca ) and the mitochondrial isoform of glycerol-3-phosphate acyltransferase ( Gpam ) (Fig