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Similarly, when we are exposed to extreme free radical insults such as from ingesting or breathing in toxins or undertaking extreme exercise we rapidly deplete our cells of its glutathione reserves resulting in injury generating oxidative stress

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Firstly, in terms of mitochondrial gene polymorphism, specific polymorphisms in the mtDNA D-loop region may be involved in the occurrence and development of IR in patients with PCOS by influencing the association between body mass index and IR (He et al., 2023)