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Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice

Some studies suggest a link between DSIP and the promotion of slow-wave sleep (SWS) and suppression of rapid eye movement (REM) sleep, while others show no correlation between the two

It is also produced endogenously when ultraviolet rays from sunlight strike the skin and trigger vitamin D synthesis

This axis is anatomically and functionally mediated by autonomic pathways (sympathetic/parasympathetic regulation of cardiovascular function), humoral factors (e.g., hormones, cytokines), and afferent signaling from cardiac receptors to brainstem and limbic regions, integrating neural, endocrine, and sensory crosstalk