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Furthermore, SF can modulate DNA methylation patterns [173]
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-KG has multiple functions in physiology by regulating epigenetic changes -KG is also a required substrate of some chromatin-modifying enzymes, including the Jumonji C domain containing lysine demethylases (KDM2-7), which are the major histone demethylases and the ten-eleven translocation hydroxylases (TET1-3) involved in DNA demethylation (Fig
