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The practicality of necroptosis, having potential as an alternative therapy for tumors resistant to apoptosis, continues to be debated
doi:10.1016/B978-0-323-88541-6.00030-2 ^ a b Garrett R.H., Grisham C.M
In this process, ROS acts as a second messenger, transmitting adequate DNL signals to promote the polarization of the macrophage M2 phenotype (110)
Among proinflammatory cytokines, TNF plays a pivotal role in inducing the production of other cytokines and expression molecules
