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Figure 5 6 Sleep disorders in cirrhosis 6.1 Prevalence, characteristics, and mechanisms Sleep disturbances worsen quality of life in cirrhosis, demanding vigilant management to uplift health-related quality of life (HRQoL) and clinical outcomes

The phenotypic remodeling of VSMCs occur during fatty acid synthesis, elongation, and -oxidation of fatty acid, and is also affected by various exogenous lipids

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Adaptive resistance is a complex process in which tumors actively remodel both their intrinsic properties and the microenvironment to evade immune attack under persistent immunotherapeutic pressure [92]