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however, long-term use of these medications often leads to significant side effects

Alpha lipoic acid treatment improved the differentiation and function of Treg cells, which contributed to the balance of Th17/Treg expression and increased Nrf2/heme oxygenase-1 (HO-1) pathway signaling

Murphy EJ, Stephens R, Jurkowitz-Alexander M, Horrocks LA

Cell Host Microbe (2012) 11:2907