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This is relevant to timeline because new blood vessel formation into avascular tissue (tendon, ligament) typically takes 7 to 14 days minimum even under optimal stimulation

At 75mg daily, most protocols observe metabolic effects within 24 weeks

Retatrutide titration: 1mg to 12mg The retatrutide titration protocol tested in Phase 3 trials follows a five-step escalation: Weeks 1-4: 1mg weekly Weeks 5-8: 2mg weekly Weeks 9-12: 4mg weekly Weeks 13-16: 8mg weekly Week 17 onward: 12mg weekly (maximum dose) The dose doubles at each step (with the exception of the 1mg to 2mg increase), which is a faster escalation rate than either semaglutide or tirzepatide

These long-term benefits need to be weighed against the evidential risk of short-term complications, especially on going sepsis should be avoided as this could be a potentially fatal condition