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Cell (2012) 149(6):126983.10.1016/j.cell.2012.04.026 8 ValenteLJGrayDHMichalakEMPinon-HofbauerJEgleAScottCLet alp53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa

Aliche-DjoudiFPodechardNChevanneMNourissatPCathelineDLegrandPet alPhysical and chemical modulation of lipid rafts by a dietary n-3 polyunsaturated fatty acid increases ethanol-induced oxidative stress

Two independent reviewers screened articles by title and abstract, followed by full-text assessment to exclude studies not primarily related to DPN, with disagreements resolved through consensus

3) Potential off-target effects: At high doses, they may disrupt normal lipid metabolism or mitochondrial function