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No documented copper toxicity occurs at recommended doses, with toxic thresholds 300-3,750 times higher than therapeutic ranges

C co-treatment with linezolid provided significant protective effect against inflammation through reduced serum lactic acid (2.227 0.2813 pg/mL), TNF- (61.05 2.036 pg/mL), and IL1 (85.5 4.826 pg/mL) levels compared to the linezolid-treated group

Studies such as those by Nishida et al

Finally, we discuss emerging strategies to interrogate and modulate this circuit using integrated omics, CRISPR-based screening, and pharmacological approaches, emphasizing the need for context-aware and temporally controlled metabolic interventions to enhance T cellbased immunotherapies in solid tumors