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[DOI] [PubMed] [Google Scholar] 57.Sela D.A., Garrido D., Lerno L., Wu S., Tan K., Eom H.J., Joachimiak A., Lebrilla C.B., Mills D.A

Differences in baseline patient characteristics, including a lower concurrent use of other ALS therapies in PHOENIX compared to CENTAUR, might also have influenced outcomes

Accumulated cholesterol in late endosomes and lysosomes impairs NPC1mediated trafficking and disrupts acidification, thereby inhibiting autophagic flux and reducing syn degradation [227, 228]

Mitochondria, which import GSH yet have no disulfide-dithiol exchange exchange with the cytosol [99], have their own dedicated Trx system (TrxR2, Trx2, and Prx3) and GSH system (Gsr, Grx2, 3, and 5, and Gpx1, 3, and 4)
