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Nature (2021) 593:225 17 LucaNFutterMLangaasS
In vitro degradation studies have shown that PROTAC 25 is able to rapidly induce the degradation of CDK6 (DC 50 = 2.5 nM, D max = 96%) and CDK4 (DC 50 = 10.5 nM, D max = 100%) proteins
This review discusses the role of GPx-1 in these diseases and speculates on potential future therapies to harness the beneficial effects of this ubiquitous antioxidant enzyme
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