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Imagine a situation where someone has a spinal cord injury above T6 with sensory loss below the level of the injury

The second-order neurons express orexigenic peptides that are melanin-concentrating hormone (MCH) and orexins A and B

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Immediately following injury (days 1 and 2), there was a more pro-inflammatory environment, as evident by the abundance of Ccr2 + monocytes/macrophages
