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The overall pattern of Bax and NF-B expression is strongly influenced by timing, PRP formulation, platelet activation state, and dosing

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Furthermore, current pharmacogenetic models suggest that the combined influence of pharmacokinetic genes (e.g., CYP2D6 and CYP2C19 ) and pharmacodynamic genes (e.g., SLC6A4 , HTR2A , BDNF ) collectively shape antidepressant response (Li et al., 2024

The slow timeline discourages many users who quit before seeing benefits
