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This initiates rapid activation of NF-B and MAPK signaling, resulting in the production of pro-inflammatory cytokines (e.g., TNF-, IL-1, IL-6) and chemokines (e.g., C-X-C Motif Chemokine Ligand 8 (CXCL8), CC Motif Chemokine Ligand 2 (CCL2)), which recruit immune cells to irradiated tissues [65]

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doi: 10.1590/1414-431x20176853

These canonical functions positioned DHODH primarily as a metabolic enzyme critical for nucleotide biosynthesis and cellular proliferation, before its more recent identification as a mitochondria-specific ferroptosis suppressor in select cancer contexts