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Nerves that course along the cartilage and ribs can also be inflamed, causing additional pain and dysfunction with each breath

Also, we should acknowledge that animal models although quite different (Schachtrupp et al., 2007) (here, 25, 30, 40, and 50 mm Hg by intraperitoneal insufflation of ordinary air controlled and maintained by a manual manometer leads to invariable abdominal compartment syndrome), correlate fairly well with the circumstances in humans

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The systemic bioavailability of the drug (F) can be predicted from the extent of absorption (f) and the extraction ratio (ER): A drug such as morphine is almost completely absorbed (f = 1), so that loss in the gut is negligible