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But the gap between those results, the side effect profiles, the costs, and the long-term sustainability of each approach has grown so wide that choosing the wrong one for your situation could mean years of frustration

Zheng and Conrad, 2020)

The focus shifts from tolerability to efficacy: is the patient losing weight at an appropriate rate, are metabolic markers improving, is the musculoskeletal system adapting well to increased activity

Flora SJ, Gupta R