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All the animal experiments were approved by humanistic animal care standards and authorized by the Laboratory Animal Ethics Committee of Jinan University

Group 4: pristane - treated animals were treated intravenously with liposomal-glutathione in a dose of 5 mg/kg daily for 30 days [15]

H&E and Ki67 immunostaining were also carried out to investigate the histological changes of gliomas in mice

Moreover, targeting methionine cycle enzymes to both regulate SAMe availability and SAMe-independent regulatory effects, particularly in methionine-dependent cancers such as colorectal and lung cancer, presents a promising therapeutic approach