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Considering the time-sensitivity of influenza protection, they had combined high-performance liquid chromatography (HPLC) with MN-based injection, effectively providing protection against multiple antigen variants ( in vivo retention of virus antigen compared to traditional intramuscular injections and may serve as an effective route of immunization ( In addition, fluoropolymer-modified nanovaccines (FiR MNVs) for rabies were delivered via MN, significantly enhancing neutralizing antibody levels and providing 6 weeks of complete protection (Figure 2) ( FIGURE 2 2.1.3 Vaccines against bacterial diseases Neisseria gonorrhoeae , the bacterium responsible for gonorrhea infections, had produced a significant number of gonorrhea patients globally and had gradually developed resistance to anti-microbial drugs over the years