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Patients with T2DM reportedly have GSH deficiency when compared to healthy controls [18]

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The ENS affects bone by secretion of neuropeptides like substance P, which may enhance bone formation (274, 275), and secretion of molecules like vasoactive intestinal peptide, which may suppress osteoclast activity and bone resorption (276)

Although this might be seen as a positive for increasing cysteine and glutathione, in fact it is thought that the excess of cystathionine is overall negative and could flood and impair the other pathways below, or specifically increase ammonia
